Which Linux distro to use on EC2?

I am setting up nginex, apache, python django, mysql based application
on EC2. I expect high web traffic and high mysql query usage. Mysql
and web server will on seperate servers.

Which linux distro should I use for heavy production use - Ubuntu,
Centos or Debian?

Does it matter?

I see most instructions on web is using Ubuntu and it seems it is
considered easiest to set up. But I read somewhere that Ubuntu is not
for server use. What is the downside if I chose ubuntu?

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