Variations on a table for different clients?

Does anyone have any experience with working with systems where different clients all need variations on the same basic table; there might be, say, 10 common fields, but each client will need an additional 2 or 3 that are specific to them (and, possibly, not need 1 or 2 of the common ones).  

What approaches or practices will help streamline work and prevent such variations from becoming a headache to maintain?  (And yes, its likely to be more than one table that will require these variations).

Thanks

Derek

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