SystemError from django.conf.settings

So I have this stack trace on my production server. I can't reproduce
it locally and it doesn't occur with an older version of the same site
deployed on the same server.

Traceback (most recent call last):
File "./dependencies/django/core/handlers/wsgi.py", line 222, in
__call__
from django.conf import settings
SystemError: ../Objects/tupleobject.c:118: bad argument to internal
function

Some details:
- nginx 0.8.54
- uwsgi 0.9.7.2
- django 1.3 (previous version which is working is 1.2.5)
- python 2.5.2
- debian 5.0.8

Since the older deployment which is running fine I have added some new
apps:
- django.contrib.comments
- south
- cumulus
- pagination
- taggit
- djangoratings
- compressor

Plus added a few extra custom settings for the various apps. So on
with the questions:

1. Anyone seen this before? The only other reference that I can find
to that line of python is here (http://bugs.debian.org/cgi-bin/
bugreport.cgi?bug=581626)

2. Any tips on how I can find out what has changed to cause it? Aside
from rolling back through weeks of revisions to find what triggered
it.

3. I am about to try upgrading python to a newer version, is that
likely to make any difference? I have already tried 2 different
versions of uwsgi (0.9.6.8 and 0.9.7.2), but I don't want to mess
around with the production environment too much, or risk breaking the
live sites.

Cheers-

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