Hosting multiple sites on a single application

Hi 

I am trying to run around 50 mini sites which share about 90% of their code. Each site simply queries and API and returns the results, and will be on it's own domain, and have a different style.css and config.py. The userbase (and the database generally) will be shared across the board. My initial idea was to run them as separate applications with a common library, each with their own UWSGI thread. However, I have concerns about large memory use. 

I have read about the sites framework which would allow them to run from a single instance.

https://docs.djangoproject.com/en/dev/ref/contrib/sites/

My question is, is the site framework the right approach to a problem like this, and does it have real benefits over running separate applications. I have heard the following:

Your SITE_ID is set in settings.py, so in order to have multiple sites, you need multiple settings.py configurations, which means multiple distinct processes/instances. You can of course share the code base between them, but each site will need a dedicated worker / WSGIDaemon to serve the site.

Alternative ideas of systems:

https://github.com/iivvoo/django_layers

https://github.com/shestera/django-multisite 

Any ideas or help would be most appreciated.

James

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